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		ViraZyme® Technology Platform The technology approach we call ViraZyme® leads to the simultaneous and parallel development of diagnostic and therapeutic products. While most companies utilize one specific technology to develop a diagnostic and a totally different one to develop therapeutics, ZymeTx's research, focuses on key targets of viruses that are encoded by the infectious organism. These targets are essential enzymes that viruses use for replication, maturation or infectivity; more specifically the target is the enzyme active-site or "groove" within this protein. Because this active-site "groove" is small and protected itself from attack by huge protecting antibodies, the parts of this active-site "groove" have been conserved for many years, while it has mutated the outer surface and other parts of this enzyme to evade antibody attack. Small molecules, however, will fit into the viral enzyme's active-site "groove". The small molecules that enter and these "grooves" are called "substrates" while small molecules that "plug-up" these "grooves" are called "inhibitors". It is the identification and development of these small molecules as substrates and inhibitors that constitutes the ViraZyme® technology. These small molecules can be likened to a specific key that fits into a virus' enzyme active-site "groove". The small molecules need to be specific as a key to fit into the "groove". ZymeTx has identified and developed small molecules that fit only into the active-site "groove" of influenza type A and B neuraminidase. The research and development towards both the diagnostic and therapeutic product proceeds simultaneously because it is the active-site "groove" that is the target of both research programs. As each product develops further along, the final stages of development diverge to accommodate the end use of these small molecules. ViraZyme Technology ViraZyme is a rational design technology based on targeting active sites on viral enzymes using X-ray crystallography and molecular modeling. Compounds are designed to interact with specific viral enzyme targets.
		Product Type  Viral Condition  Compound  Identifier  Stage  Laboratory  Diagnostic  Parainfluenza Types  1,2,3, & 4 and  Influenza Types A & B  ZstatFlu®  Culture Screen  ZX-0209  FDA Cleared  Viral Point of Care  Diagnostic  (20 min. version)  Influenza Type A & B  ZstatFlu®  ZX-0321  FDA Cleared  Viral Point of Care  Diagnostic  (20 min. version  with portability)  Influenza Type A & B  ZstatFlu®  ZX-0321  FDA Cleared  Viral Therapeutic  Influenza Type A & B  ZX-0610  Research  Viral Therapeutic  Influenza Type A & B  ZX-0620  Research  Viral Therapeutic  Influenza Type A & B  ZX-0791  Animal Testing  Viral Therapeutic  Influenza Type A & B  ZX-0792  Animal Testing  Viral Therapeutic  Influenza Type A & B  ZX-0793  Animal Testing  Viral Therapeutic  Herpes Simplex  Types I & II  ZX-1291  Research  Viral Therapeutic  Herpes Simplex  Types I & II  ZX-1292  Research  Viral Therapeutic  Herpes Simplex  Types I & II  ZX-1293  Research ViraSTAT® Technology ViraSTAT technology is a proprietary monoclonal antibody production process that results in superior laboratory diagnostics.    Product Type  Viral Condition  Compound  Identifier  Stage  Laboratory  Diagnostic  Parainfluenza Type 1  ViraSTAT  Para-1  ZX-0119  FDA Cleared  Laboratory  Diagnostic  Parainfluenza Type 2  ViraSTAT  Para-2  ZX-0129  FDA Cleared  Laboratory  Diagnostic  Parainfluenza Type 3  ViraSTAT  Para-3  ZX-0139  FDA Cleared  Laboratory  Diagnostic  Influenza Type A  ViraSTAT  Flu-A  ZX-0419  FDA Cleared  Laboratory  Diagnostic  Influenza Type B  ViraSTAT  Flu-B  ZX-0429  FDA Cleared Additional therapeutic technologies in research.  Product Type  Viral Condition  Compound  Identifier  Stage  Therapeutic  Viral Gene Delivery  GD19  Research and  Pre-clinical  Testing  Therapeutic  Viral Interference  PP20  Research  Therapeutic  Modified Ethnobotanical  Therapeutics  EB21  Research and  Pre-clinical  Testing
			ZymeTx Web Sites: zymetx.com flu101.com fluwatch.com ©2003 - ZymeTx, Inc. ZstatFlu®, ViraZyme®, and ViraSTAT® are trademarks of ZymeTx, Inc.